Technical Control | What factors should be considered when developing an immunization procedure? – Pig Pig School – China Animal Husbandry Website – A useful animal husbandry website
Immunization is one of the most important means of preventing and controlling diseases. The basic principles developed by the pig farm immunotrophic procedural are the prevailing programs for the development of animal health and different vaccine characteristics according to the prevalence of infectious diseases in a certain region or in the farming field, including the type, order, time, time of vaccination. , The number, method, interval, and other procedures and order.
Generalized immunotrophic procedures refer to a kind of pig farm requires the type, inoculation of vaccination, inoculation requirements. A narrow immunotype is to refer to a vaccine, a number of vaccines, number of immune times, two inocution intervals (basic immunization time and time to enhance immunity). What vaccination is vaccinated, how should each vaccine determine, it is the most concerned issue of pig farm. At present, there is no immunization process in China that can be universal, and the immunization procedures of others can do not have to work. Here is an immunized procedure used in a north, for reference only.
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Domestic sow immunoassay
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Commodity pig immunity
in fact, it is bestThe practice is based on the occurrence of diseases in each pig farm, considering the epidemic characteristics of the disease in the region, combined with the type, age, feeding management of pigs, and the nature of the vaccine, the type and immunological pathway. Aspects of factors and immunoassays, formulated an immune procedure for this site. When developing an immunization process, I think it is important to consider the following factors:
1. Mother-antibody interference problem
passive immunization of the mother’s source of antibody is very important to new studios, however for vaccine Inoculation also brings a certain impact. The key to the immunization procedure is to eliminate maternal antibody interference, and determine the right prevention date. It is preferred to select the maternal antibody in the piglet that does not affect the vaccine immune effect and can prevent viral infections. If the vaccination is vaccinated in the parent antibody effect, it will be neutralized by the parent antibody and the disappear of the vaccine, and the piglets cannot produce strong active immunity.
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Therefore, there is no need to vaccinate the disinfection vaccine when the parent antibody level is high. For example, the piglet immunization procedure of piglets is generally taken from 25 to 30 days, and the interval is reinforced once in 55 to 60 days of age. For example, a pseudohadia’s immunization process, according to the size of the pig field infection, determine whether to perform a 1-day-old pig nasal spray immunity, first immunoir in 8 ~ 10 weeks old, enhanced immunomotram in 4 weeks after 4 weeks.
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2, the history of pig farms
When the immunoassay is developed, the epidemic epidemic situation of pig farms and what disease has been happened, Activity, pathogenesis, and pathogenesis, which determine the type of vaccine and immune time. For the region, the new epidemic disease has not been confirmed, must have been confirmedImmunization is carried out in a serious threat.
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3, the immunity pathway
The pathway of vaccination has injection, drinking water, drops, etc., according to the type of vaccine, the characteristics of the disease and the immunoassay, each time Immunization of inoculation pathways. For example: inactivating seedlings, cychetic and subunit seedlings can not be inoculated with digestive tract, generally used for muscle injection; domestic pig gas, weak toxic freeze-dried dry seedlings use chest vaccination, some use nasal spray immunity; pseudohadia disease (GE- Gi-) Dual gene lack of seedlings is better to the piglet nasal immunity, which can establish an immunization barrier to avoid the interference of the mother’s antibody. The reasonable immune pathway can stimulate the rapid addition of the body to generate an immune response, and inappropriate immune pathways may result in immunity failure and adverse reactions. The same vaccine is different from the immune effect obtained by different immune pathways.
4, seasonal prevention of epidemic disease
The epidemic of some diseases has a certain seasonality, such as spring prevention of swine flu, summer prevent Japanese encephalitis, autumn and winter to prevent contagine gastroenteritis And epidemic diarrhea. 5, interference between different vaccines and scientific arrangements of inoculation time
When the vaccine without cross-reactive vaccination is immunized, the body is immunized in one of the vaccine. The response will be reduced, so in order to ensure the immunization effect, it is best to inoculate the local comparative epidemic, and the vaccination of the vaccine has antagonistic effects before generating immunity, especially, after immunization If the pig farm is infected with viruses, due to the antigen (vaccine) competition, the body does not produce an immune response to the infected virus. At this time, the incidence is likely to be serious than the vaccination. Therefore, in the vaccination of Pig Pseudohavior (PR), the immunojection of the Pork fever (HC) rabbit is a week to avoid the immune interference of HC.
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6, immune must be combined with monitoring
Vaccine 4 weeks after immunization Active monitoring is successful; 3-4 months monitor antibody maintenance time.
First level: control pig disease, reduce death
Second level: scientific immunity, pigs must not be sick
1. Monitor the immunity effect and overall protection level.
2, provide a basis for the development of a reasonable immunization process. 3, early / auxiliary / quick diagnosis. 4, quarantine phase-out positive strain pigs.
Third level: Purification of pigs.
In summary, the immunotype procedural development needs to consider the immunization of pigs, epidemic, local epidemics, vaccine immunogenesis, immune time, part, frequency, etc. Therefore, each pig farm needs to be tailored to the immunization procedure in combination with its own condition; while needing to improve its continuous optimization adjustment with a perfect epidemic and immune effect monitoring system, thereby establishing a strong and effective epidemic prevention barrier!
Original article, author：xinran，If reprinted，Please indicate the source：http://www.badpet.org/technical-control-what-factors-should-be-considered-when-developing-an-immunization-procedure-pig-pig-school-china-animal-husbandry-website-a-useful-animal-husbandry-website/