Technology 丨 Aquatic experts explain the role of bile acid in excessive accumulation of fish fat – Aquatic Forum – China Animal Husbandry Website – A useful animal husbandry website

After the China-US trade war, the “low protein day grain formula” became the focus of everyone discussed. People hope to reduce the use of low protein day grain formulation technology, reduce the “fat saving protein” technology In the feed formulation, the amount of oil usage is increased, and the purpose of reducing the use of feed protein raw materials can also be used. However, there is a study showing that the oil level is raised, the aquaculture fat intestinal membrane fat index, the liver fat content and significantly increased, causing fish “big belly”, fatty liver and other lipid metabolic obstacles.

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Different with mammals, fish lack of subcutaneous fat layers, the main fat accumulation site is abdominal intestinal membrane adipose tissue, liver and muscle. Excessive fat in the abdominal cavity caused a “big belly” problem, and excess fat accumulates the fatty liver problem in the liver. Fat accumulation makes fish’s nutritional metabolism, decreased production performance; cause immune system disorders, resulting in decline in disease resistance, easy to enabling large-scale infectious fish disease, is subject to environmentally stimulating (such as pull network, Transportation, water temperature mutation, poor water quality, etc., it is easy to occur, even a large number of deaths. WeChat picture _20181012090114.jpg

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Nutrient imbalance in feed, lack of trace elements, oxidation of feed raw materials, and excessive feeding are nutrient factors that cause excessive fish fat excessive accumulation. Reduce fish excess fat accumulation, in addition to pay attention to nutrient balance in feed, it is also necessary to consider adding substances that regulate lipid metabolism, such as vitamins, Chinese herbal medicines, bile acids, conjugated linic acids, etc. in the feed. Among them, bile acids can reduce fish excessive fat accumulation, but also improve protein conversion, promote increased fish body weight, and have an irreplaceable role than other damping factors. Professor of bile acid and high unsaturated fatty acid (HUFA)The effect of Hufa on the grassfish, it is considered that the HUFA is not necessary fatty acids, but the addition of Hufa in the feed indicates that the growth of the grass fish has a positive effect, which can significantly reduce the abdominal fat index of the grass fish, promote the growth of the grass, promote fat cell hydrolysis Inhibit the accumulation of grass fish. Hufa’s role is to first need to be digested by fish as other lipid substances. Since non-specific biliary active lipase (BAL) and HUFA is not only strong, but also has specificity, HUFA lipids can enhance the affinity of lipids and digestive enzymes and emulsification of lipids in the digestive tract, thereby increasing HUFA Digestion of lipids in the fish body digestive tract. The HUFA lipid is extremely polarized than the saturated fatty acid and the lipids of the monoquiol fatty acid, which is more susceptible to bile acid emulsion, thereby increasing the substrate and the enzyme contact area to promote lipid digestion. At the absorption stage of the lipid, since the HUFA melting point is low and the polarity is high, the non-agitated aqueous layer (UWL) of the formation of cholesterol, phospholipid and bile acid forming micro group through the mucosal contact is adjusted to the microveree surface. Intestinal epithelial cells. Therefore, the bile acid added in the feed promotes the digestion of the HUFA in the feed, thereby enabling HUFA to inhibit the effects of fat accumulation in vivo. The cause of the bile acid and the fixhanol X receptor (FXR) caused fish fat accumulation, nothing more than three aspects, that is, there are too many fat “come”, the decomposition is too small and “out”, “out” less That is, fat is less transferred from the accumulation site. Bile acid acts as a signal molecule to activate many nuclear receptors in the liver and gastrointestinal tract, such as the FXR X-receptor (FXR), which can induce SHP gene expression after bonding FXR, and SHP causes SREBP-1C gene expression to control fatty acids. The synthesis ratio, SHP causes the PPARα gene to promote lipid decomposition.

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Bile acid and liver function feed in the liver fat, mold toxin, etc., will damage the fish liver, resulting in decline in liver function, affecting lipid metabolism, “yellow fat” in some areasAlong with the excessive fat deposition in the abdomen. In addition to the regulation of lipid metabolism by FXR, the bile acid reducing fat in the liver deposits, and can also maintain the role of liver health in the following two points. First, in combination or decompose endotoxin in the intestine, prevent endotoxin from entering the liver through the intestinal mucosal barrier, reducing the absorption of the intestinal toxins to prevent endotoxins from harm to intestinal, liver or even fish. The second is to promote the secretion of hepatocytes with a large amount of thin bile, and other harmful substances such as mold toxins, heavy metals and drugs are excluded from the bile, thereby reducing the damage of the toxic substance on the liver, and maintains the health of the fish. By increasing the content of fat in the feed to reduce the purpose of the protein raw material in the feed, it is necessary to consider the digestive absorption rate of fat, but also considering the metabolism of fat, but also considering that protein efficiency, not only just reduces fat accumulation, but also It has to increase the synthesis of protein, which achieves the purpose of improving body type and increasing income. The article is from the official website of Shandong Longxuan.

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